Link to pubmed listing of publications

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Published Manuscripts

*Co-first Author

^Undergrad mentee

Metzger, B. P. H., & Wittkopp, P. J. (2019). Compensatory trans-regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae. Evolution Letters. doi:10.1002/evl3.137.

Duveau, F., Hodgins-Davis, A., Metzger, B.P.H., Yang, B., Tryban, S., Walker, E., Lybrook, P., and Wittkopp, P.J. (2018) Fitness effects of altering gene expression noise in Saccharomyces cerevisiae. eLife. 7:e37272.

Yuan, D.C.*, Duveau, F.*, Metzger, B.P.H., Hodgins-Davis, A., and Wittkopp, P.J. (2018) Effects of mutations and selection on plasticity of TDH3 promoter activity in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 114(52):E11218-E11227.

Maclean, C.J.*, Metzger, B.P.H.*, Yang J.-R.*, Ho, W.-C., Moyers, B., and Zhang, J. (2017) Deciphering the genic basis of environmental adaptations by simultaneous forward and reverse genetics in Saccharomyces cerevisiae. Molecular Biology and Evolution. In press.

Metzger, B.P.H., Wittkopp, P.J., and Coolon, J.D. (2017) Evolutionary dynamics of regulatory changes underlying gene expression divergence among Saccharomyces species. Genome Biology and Evolution. 9(4):843–854.

Metzger, B.P.H.*, Duveau, F.*, Yuan, D.C.*, Tryban, S., Yang, B., and Wittkopp, P.J. (2016) Contrasting frequencies and effects of cis- and trans-regulatory mutations affecting gene expression. Molecular Biology and Evolution. 33(5):1131-1146.

Metzger, B.P.H.*, Yuan, D.C.*, Gruber, J.D., Duveau, F., and Wittkopp, P.J. (2015) Selection on noise constrains a eukaryotic promoter. Nature. 521:344-347.  

Duveau, F., Metzger, B.P.H., Gruber, J.D., Mack, K., Sood, N.^, Brooks, T., and Wittkopp, P.J. (2014) Mapping small effect mutations in Saccharomyces cerevisiae: impacts of experimental design and mutational properties. G3: 1205-1216. 

Metzger, B.P.H., Gelembiuk, G.W. & Lee, C.E. (2013) Direct sequencing of haplotypes from diploid individuals through a modified emulsion PCR-based single-molecule sequencing approach.  Molecular Ecology Resources, 13, 135–143.  

Manuscripts in Review

& Version available upon request

Gelembiuk, G.W., Metzger, B.P.H., Silva, J.C., Lee, C.E. Shifts in copepod microbiome composition across replicated saline to freshwater invasions. In Revision. &

Manuscripts in Preparation

& Version available upon request

Hochberg, G.K.A., Liu, Y., Marklund, E., Metzger, B.P.H., Laganowsky, A., Thornton, J.W. A hydrophobic ratchet entrenches molecular complexity in the steroid hormone receptors. In prep. &

Duveau, F., Metzger, B.P.H., Vande Zande, P., Diaz, C., Walker, E., Tryban, S., Yang, B., and Wittkopp, P.J. Genomic architecture of new regulatory mutations impacting expression of a yeast gene. In prep.

Cochran, V.*, Pu, J.*, Metzger, B.P.H.*, Dickinson, B. Alternative genetic routes during the evolution of protein-protein interactions. In prep.

Park, Y., Metzger, B.P.H., Thornton, J.W. Deep mutational scanning via microarray synthesis. In prep.